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ba0001pp216 | Cell biology: osteoclasts and bone resorption | ECTS2013

Glycosaminoglycan sulfation is a key regulator of osteoclast biology and osteogenic bone cell signaling

Salbach-Hirsch Juliane , Tsourdi Elena , Ziegler Nicole , Hintze Vera , Scharnweber Dieter , Moller Stephanie , Schnabelrauch Matthias , Rauner Martina , Hofbauer Lorenz

In light of prolonged life expectancy, the need for biomaterials that govern bone regeneration increases. Improved bone regeneration and osseointegration can be achieved by funtionalizing implant materials. The extracellular matrix (ECM) affects differentiation of bone cells and is critical for bone regeneration. Here we assessed the role of the natural occurring bone ECM glycosaminoglycans (GAGs) hyaluronan (HA) and chondroitin sulfate (CS), and their sulfated derivatives, on...

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ba0005p72 | Bone development/growth and fracture repair | ECTS2016

Sulfated hyaluronan improves bone defect healing in type 2 diabetic rats by increasing osteoblast function

Picke Ann-Kristin , Salbach-Hirsch Juliane , Hintze Vera , Rauner Martina , Moller Stephanie , Kascholke Christian , Hacker Michael C , Schulz-Siegmund Michaela , Schnabelrauch Matthias , Scharnweber Dieter , Hofbauer Lorenz C , Hofbauer Christine

Bone fractures of patients suffering from type 2 diabetes mellitus (T2DM) represent an emerging socioeconomic problem. Underling mechanisms are poorly understood and therapies are limited. Our previous studies have shown that sulfated hyaluronan (sHA3) suppresses osteoclast activity while supporting osteoblast function in vitro. Hence, we now investigated if sHA3 can improve the delayed fracture healing in rats with T2DM.Porous, cross-linked lactide-base...

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Bone Abstracts

Glycosaminoglycan sulfation is a key regulator of osteoclast biology and osteogenic bone cell signaling

Sulfated hyaluronan improves bone defect healing in type 2 diabetic rats by increasing osteoblast function

BiosciAbstracts